Chapter 1

Embryonal stem cell research
http://www1.umn.edu/stemcell/sci/page/reseach/rech-edu-v1.shtml
http://www.nih.gov/news/stemcell/082701list.htm
http://www.nih.gov/news/stemcell/primer.htm
http://www.news.wisc.edu/packages/stemcells/
http://www.newscientist.com/hottopics/cloning/

Chapter 2

Gel electrophoresis techniques and simulations
A wonderful website that includes links to a virtual lab on agarose gel electrophoresis:
http://arbl.cvmbs.colostate.edu/hbooks/genetics/biotech/gels/
A Massachusetts Institute of Technology website dealing with Southerns, Northerns, Westerns, and cloning:
http://web.mit.edu/esgbio/www/rdna/rdna.html
2-D gel electrophoresis of proteins:
http://www.fitzscipress.com/Chap05.pdf
A website containing lots of links to electrophoresis techniques and simulations:
http://biobenchelper.hypermart.net/pr/electrophoresis.htm
Want to learn more about chemical bonds? Check out this website:
http://hyperphysics.phy-astr.gsu.edu/hbase/chemical/bond.html

Chapter 3

Additional images of nucleic acids:
http://www.imb-jena.de/ImgLibDoc/nana/IMAGE_NANA.html
A DNA structure activity:
http://www.biology.arizona.edu/biochemistry/activities/DNA/DNA.html
A great website with lots of animations and links to a wealth of additional resources:
http://www.umass.edu/microbio/chime/dna/index1.htm
MyDNA-a wonderful website with lots of DNA-related tutorials, animations, resources, and thought-provoking articles on DNA-related ethical issues:
http://www.bio.umass.edu/biochem/mydna/
The MIT Biology Hypertextbook, with links to numerous additional resources:
http://web.mit.edu/esgbio/www/

Chapter 4

For general information on protein structure and function:
http://web.mit.edu/esgbio/www/lm/lmdir.html
http://www.biophysics.org/btol/protein.html
http://www.faseb.org/protein/ProTeach/ProTeach2/
John Kendrew's 1962 Nobel Prize Lecture on Myoglobin and the Structure of Proteins
http://www.nobel.se/chemistry/laureates/1962/kendrew-lecture.pdf
Want to learn more about prions and prion diseases? Check out these websites:
http://science-education.nih.gov/nihHTML/ose/snapshots/multimedia/ritn/prions/prions1.html
http://www.cmpharm.ucsf.edu/~wallacea/nobel.html
http://www.uchospitals.edu/news/2000/20000128-prionmodule.html
http://www.uchospitals.edu/news/1997/19971209-madcow.html
http://www.nigms.nih.gov/news/releases/brief_lindquist.html

Chapter 5

Want more information on histones and chromatin? Please consult these online resources:
http://www.chromatin.net/
http://www.nih.gov/news/NIH-Record/10_02_2001/story03.htm
http://cellbio.utmb.edu/cellbio/nucleus.htm
A virtual tour of the nucleosome:
http://www.average.org/~pruss/nucleosome.html
To learn more about cell membranes, check out these websites:
http://www.web-books.com/MoBio/Free/Ch1B.htm
http://www.cytochemistry.net/Cell-biology/membrane.htm
http://ntri.tamuk.edu/cell/membranes.html

Chapter 6

For a first-hand description of the transformation experiments, including video clips of interviews with Maclyn McCarty, please go to this amazing website:
http://www.dnaftb.org/dnaftb/concept_17/con17av_left.html
http://www.dnaftb.org/dnaftb/17/concept/index.html
For additional information on the transformation experiments:
http://profiles.nlm.nih.gov/CC/A/A/O/J/_/ccaaoj.pdf
http://web.mit.edu/esgbio/www/pge/tools.html

Chapter 7

Some DNA Replication animations:
http://www2.kenyon.edu/Depts/Biology/courses/biol14/slides/slides-2.html
http://www.irn.pdx.edu/~newmanl/DNArepl1.mov
http://www.mhhe.com/biosci/genbio/animation_quizzes/graphics/lem6s2b.ram
From the Dolan DNA Learning Center at Cold Spring Harbor Laboratory:
http://www.dnalc.org/
DNA From the Beginning- an outstanding online learning resource from The DNA Learning Center at Cold Spring Harbor Laboratory. You will find explanations of important concepts, animations, image galleries, audio/video clips, biographies, problems, and links!!!
http://www.dnaftb.org/dnaftb/

Chapter 8

For a wealth of information on RNA, transcription, and RNA processing, consult the following websites:
http://www.dnaftb.org/dnaftb/
http://www.lsic.ucla.edu/ls3/tutorials/gene_expression.html
http://web.indstate.edu/thcme/mwking/rna.html
http://www.life.uiuc.edu/bio100/lectures/s02lects/14s02-dnatoprot.html
For more information about RNA polymerase:
http://www.mun.ca/biochem/courses/3107/Lectures/Topics/RNAP_bacterial.html
For a great animation of Southern Blotting:
http://www.dnalc.org/resources/BiologyAnimationLibrary.htm

Chapter 9

For a wealth of information on translation and the genetic code, please consult the following websites:
http://tidepool.st.usm.edu/crswr/protsynthmov.html
http://www.dnaftb.org/dnaftb/
http://www.dnaftb.org/dnaftb/22/concept/index.html
http://www.lsic.ucla.edu/ls3/tutorials/gene_expression.html
http://web.indstate.edu/thcme/mwking/protein-synthesis.html
http://www.life.uiuc.edu/bio100/lectures/s02lects/14s02-dnatoprot.html
http://www.dnalc.org/

Chapter 10

For additional information on chemical mutagens and their specific modes of action, you may wish to consult:
http://www.life.uiuc.edu/micro/316/topics/mutations/mutagens.html
For some general information on DNA repair and DNA repair mechanisms:
http://www.nih.gov/sigs/dna-rep/whatis.html
http://www.er.doe.gov/feature_articles_2001/June/Decades/83.html
http://www.nature.com/celldivision/library/repair.html
For additional information on the SOS response:
http://www.weizmann.ac.il/Biology/open_day/book/zvi_livneh.pdf
To learn more about mismatch repair in E. coli
http://www.niddk.nih.gov/welcome/releases/10-12-00.htm
Want to learn more about DNA repair and cancer?
http://www.news.harvard.edu/gazette/2002/06.13/06-cancergenes.html
http://www.noah-health.org/english/illness/cancer/cancgen.html#BREAST
http://www.cancer.gov/cancer_information/doc_pdq.aspx?viewid=A4DD5637-EDE7-47C1-8F75-049D2E6BD550
http://www.cancer.gov/CancerInformation/CancerType/colonandrectal
http://www.oncolink.com/
http://www.nlm.nih.gov/medlineplus/colorectalcancer.html
http://www.nlm.nih.gov/medlineplus/breastcancer.html
http://www.nlm.nih.gov/medlineplus/ovariancancer.html
http://www.nlm.nih.gov/medlineplus/skincancer.html
Want to learn more about xeroderma pigmentosum?
http://www.moonchildren.com/welcome.html
http://www.cc.nih.gov/ccc/patient_education/pepubs/xeroderma.pdf
http://xpsupportgroup.org.uk/
http://www.xps.org/ To learn more about another human genetic disorder associated with a DNA
repair defect, Ataxia telangectasia:
http://www.neuro.wustl.edu/neuromuscular/ataxia/dnarep.html

Chapter 11

For an overview of regulation of gene expression in prokaryotes, you may wish to consult:
http://www.biochemweb.org/genes.shtml
http://www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookGENCTRL.html
http://www.ndsu.nodak.edu/instruct/mcclean/plsc431/prokaryo/prokaryo1.htm
http://www.orst.edu/instruction/bb492/lectures/Regulation.html
http://www.blc.arizona.edu/marty/411/Modules/mod9.html
http://www.cat.cc.md.us/courses/bio141/lecguide/unit4/u4ib5.html#rep
For additional information on the Lac operon:
http://www.accessexcellence.org/AB/GG/induction.html
http://www.ndsu.nodak.edu/instruct/mcclean/plsc431/prokaryo/prokaryo2.htm
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/L/LacOperon.html
http://www.leeds.ac.uk/bionet/compend/bnt28pst.htm
http://www.web-books.com/MoBio/Free/Ch4D3.htm
Animations of the lac operon in action!
http://www.people.virginia.edu/~rjh9u/lacoperonanim.html
http://www.cat.cc.md.us/courses/bio141/lecguide/unit4/ionoind.html
http://www.cat.cc.md.us/courses/bio141/lecguide/unit4/ioind.html
And a wonderful movie of the lac operon!
http://www.dartmouth.edu/~cbbc/courses/movies/LacOperon.html
To learn more about catabolite repression of the lac operon:
http://www.blc.arizona.edu/marty/411/Modules/catrep.html
To learn more about the trp operon and regulation of its expression:
http://www.ndsu.nodak.edu/instruct/mcclean/plsc431/prokaryo/prokaryo3.htm
http://www.blc.arizona.edu/marty/411/Modules/trpop.html
Animations of the trp operon:
http://www.cat.cc.md.us/courses/bio141/lecguide/unit4/u4ib5.html#rep
http://www.cat.cc.md.us/courses/bio141/lecguide/unit4/rorep.html
To learn more about the gal operon and its regulation:
http://www.eurekalert.org/pub_releases/2002-06/cshl-ssw062502.php
http://www.blc.arizona.edu/marty/411/Modules/mod11.html

Chapter 12

For an overview of regulation of gene expression in eukaryotes, you may wish to consult:
http://www.indstate.edu/thcme/mwking/gene-regulation.html
http://www.ndsu.nodak.edu/instruct/mcclean/plsc431/geneexpress/eukaryexlinks.htm
http://www.emunix.emich.edu/~rwinning/genetics/eureg.htm
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/Promoter.html
For information on chromatin structure and fucntion, please consult:
http://www.cstone.net/~jrb7q/chrom.html
http://www.cstone.net/~jrb7q/caps.html
http://mitglied.lycos.de/whennig/LCRrev.pdf

For a comprehensive overview of the differences between euchromatin and
heterochromatin, please see:
http://www.euchromatin.net/
For information on methylation and regulation of gene expression:
http://www.ndsu.nodak.edu/instruct/mcclean/plsc431/geneexpress/eukaryex5.htm
http://www.web-books.com/MoBio/Free/Ch4G.htm
http://emboj.oupjournals.org/cgi/content/full/17/17/4905
To learn more about acetylation of histones and regulation of gene expression:
http://depts.washington.edu/luca201/05_01_01.pdf
Some additional information on mRNA editing:
http://eos.bio.tu-darmstadt.de/newww/microbiology/goeringer/homann/vorl23.pdf
http://www.cc.ndsu.nodak.edu/instruct/mcclean/plsc731/genome/genome9.htm
http://www.rna.ucla.edu/trypanosome/
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/R/RNA_Editing.html
http://www.euchromatin.org/mcmanus01.htm
To learn more about immunoglobulin gene rearrangement:
http://www.infobiogen.fr/services/chromcancer/IntroItems/PolyIgEng.html
http://opbs.okstate.edu/~melcher/MG/MGW3/MG3243.html
http://www.whfreeman.com/immunology/CH07/kuby07.htm

Chapter 13

Genome data base (an official human genome project site):
http://gdbwww.gdb.org/
Genome research is highlighted at this site:
http://www.nature.com/genomics/
Genomics and world health is featured at this site, with links to a collection of interesting reports:
http://www3.who.int/whosis/genomics/genomics_report.cfm
http://www.ornl.gov/hgmis/publicat/primer2001/
Microbial genomics:
http://www.microbialgenome.org/
Protein Data Bank:
http://www.rcsb.org/pdb/
An extensive bioinformatics site can be found at:
http://www.nwfsc.noaa.gov/protocols/bioinformatics.html
Human proteomics is described at:
http://us.expasy.org/sprot/hpi/hpi_desc.html

Chapter 14

Animation of F plastid insertion into the E. coli chromosome
http://www.people.virginia.edu/~rjh9u/IntroBio/fplasmidinsertion.html
Genetic map of the F plasmid
http://www.people.virginia.edu/~rjh9u/IntroBio/fplasmidmap.html
Animation of bacterial conjugation and gene transfer
http://www.hhmi.org/lectures/biointeractive/animations/conjugation/conj_frames.htm
Animations of viral replication:
http://icb.usp.br/~mlracz/animations/kaiser/kaiser.htm
Lytic life cycle of bacteriophage T4
http://www.brunel.ac.uk/depts/bl/blst/emma/molecgen/virus/lytic/lytic1.htm
Replicative transposition
http://www.life.uiuc.edu/micro/316/topics/transposons/repl-tpn.html
Lots of links to information on insertion sequences and transposons
http://www.life.uiuc.edu/micro/316/topics/transposons/
http://plantbio.berkeley.edu/~glass/PMB118_site/transposons.htm
Life cycles of lambda phages
http://www.web-books.com/MoBio/Free/Ch1F1.htm
http://biology.fullerton.edu/biol302/lambdaweb/
http://www.blc.arizona.edu/marty/411/Modules/lambda.html
http://www.brunel.ac.uk/depts/bl/blst/emma/molecgen/virus/lysogen/tempbac.htm

Chapter 15

Recombinant DNA and Gene cloning:
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/R/RecombinantDNA.html
Southern blotting and hybridization animations and illustrations:
http://opbs.okstate.edu/~melcher/MG/MGW4/MG423.html
From the Dolan DNA Learning Center at Cold Spring Harbor, animations of PCR, Southern Blotting, plus other molecular biology animations:
http://www.dnalc.org/resources/BiologyAnimationLibrary.htm
Website dealing with cloning and molecular analysis of genes:
http://www.ndsu.nodak.edu/instruct/mcclean/plsc431/cloning/clone3.htm
Some really wonderful illustrations of the techniques of genetic engineering!
http://www.uic.edu/classes/phar/phar331/lecture6/
Mama Ji's Molecular Kitchen...a wonderfully creative look at the techniques of genetic engineering, plus additional commonly-used techniques in molecular biology:
http://lsvl.la.asu.edu/resources/mamajis/index.html
Another great website containing lots of information on gene cloning, including links to other resources, and animations:
http://zoology.okstate.edu/zoo_lrc/biol1114/study_guides/labs/lab10/lab10.htm
Some information on cloning vectors:
http://www.web-books.com/MoBio/Free/Ch9A4.htm
Recombinant DNA technology animation:
http://present.smith.udel.edu/biotech/rDNA.html
DNA Microarray analysis animation:
http://www.bio.davidson.edu/courses/genomics/chip/chip.html
Interactive Gel electrophoresis animation:
http://www.shsu.edu/~chm_tgc/sounds/flashfiles/GE.swf
Links to a gazillion biology and chemistry animations:
http://science.nhmccd.edu/biol/animatio.htm
Links to animations of PCR and gene cloning techniques:
http://library.thinkquest.org/24355/data/details/media/index.html

Chapter 16

An assortment of articles on the cloning of a variety of different living organisms: from African violets to cats to humans
http://www.life.uiuc.edu/bio100/lectures/s02lects/18s02biotechclonerecomb.html
Website dealing with cloning and molecular analysis of genes:
http://www.ndsu.nodak.edu/instruct/mcclean/plsc431/cloning/clone3.htm
Some really wonderful illustrations of the techniques of genetic engineering!
http://www.uic.edu/classes/phar/phar331/lecture6/
A truly amazing global resource page on cloning, stem cell research, and related ethical issues, including recent news articles and legislative updates:
http://genomics.phrma.org/cloning.html
Animation and article on interspecies cloning:
http://www.brookscole.com/chemistry_d/templates/student_resources/0030244269_campbell/HotTopics/InterspeciesCloning.html
From PBS...an animation that illustrates how stem cells are cultivated:
http://www.pbs.org/newshour/health/stem_cells.swf
Animations illustrating the use of viruses as vectors for gene therapy:
http://www.technologyreview.com/articles/5940.htm
Animations of techniques used for cloning mammals, as well as a create-your-own-clone link!
http://library.thinkquest.org/24355/data/details/media/index.html
Another animation of PCR:
http://www.people.virginia.edu/~rjh9u/pcranim.html
Animations of restriction digests and gel electrophoresis:
http://www.biology.ucsc.edu/classes/bio20L/animate/